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目的观察分析心率变异性(HRV)对原发性高血压患者预后的影响。方法原发性高血压患者397例,以HRV的标准范围分为正常组(152例)与非正常组(245例),并对部分异常组患者进行美托洛尔治疗,设为观察组(127例);剩余非正常组患者为异常组(118例)。正常组与异常组接受常规药物治疗,观察组另行美托洛尔治疗。观察并记录所有患者24 h的动态心电图及患者的临床疗效。结果异常组患者SDNN、SDNNI、r MSSD、PNN50、HRVI的值均显著的低于正常组,而观察组与异常组相比则有所回升(P<0.05)。结论 HRV能够增加原发性高血压患者的晨峰发生率以及急速颈动脉硬化,诱发心脑血管事件;而美托洛尔则能有效的改善HRV对原发性高血压患者的影响,延缓颈动脉硬化的进程,降低心脑血管事件的发生几率。
Objective To observe and analyze the effect of heart rate variability (HRV) on the prognosis of patients with essential hypertension. Methods 397 essential hypertension patients were divided into normal group (152 cases) and non-normal group (245 cases) with HRV standard range. Metoprolol was given to some patients in abnormal group, 127 cases); the remaining non-normal group was abnormal group (118 cases). The normal group and the abnormal group received routine drug treatment, and the observation group was treated with metoprolol. All patients were observed and recorded 24 hours of Holter and the clinical efficacy of patients. Results The values of SDNN, SDNNI, MSSD, PNN50 and HRVI in patients with abnormal group were significantly lower than those in normal group (P <0.05). Conclusion HRV can increase the incidence of morning peaks and rapid carotid atherosclerosis in patients with essential hypertension and induce cardiovascular and cerebrovascular events. Metoprolol can effectively improve the effect of HRV on patients with essential hypertension, delay the neck The process of atherosclerosis, reducing the incidence of cardiovascular and cerebrovascular events.