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研究了4-氯代苯甲氧基乙酸二甲氨基乙酯盐酸盐在家兔体内的药代动力学,测定了不同时间不同给药方式家兔体内的血药浓度及动力学参数.其结果表明,4-氯代苯甲氧基乙酸二甲氨基乙酯盐酸盐静注后在家兔体内呈双室模型,消除半衰期较长,其绝对生物利用度为26%.
The pharmacokinetics of dimethylaminoethyl 4-chlorobenzyloxyacetate hydrochloride in rabbits was studied and the plasma concentration and kinetic parameters of rabbits in different administration modes were determined. The results showed that intravenous injection of 4-chlorobenzyloxyacetic acid dimethylaminoethyl ester hydrochloride in rabbits showed a double chamber model with long elimination half-life and an absolute bioavailability of 26%.