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背景:急性脑血管病(acutecerebrovasculardisease,ACVD)常致记忆功能损害,但其亚型、病灶部位与记忆障碍临床特征之间的关系仍是不清楚的。目的:研究ACVD的记忆障碍的临床特征。设计:以诊断为依据,设立对照和标准对照回顾性研究。地点和对象:研究地点为本院神经内科心理检测室。大坪医院神经内科1997-01/2000-06收治的57例住院急性脑血管病患者,其中女19例,男38例。年龄37～91岁,平均60岁。平均受教育年限10年。方法:用“韦氏记忆量表”测定ACVD患者的瞬间、短时、长时记忆和记忆商,检查者为第一作者。主要观察指标:韦氏记忆量表瞬间、短时、长时记忆分量表的量表分和记忆商。结果:各疾病组记忆总量表、短时和长时记忆量表分以及记忆商均明显低于正常对照组。出血组与缺血组,左、右大脑半球和双半球,单灶腔隙、单灶非腔隙和多灶腔隙梗死之间比较均无显著性差异,但单灶非腔隙梗死组、出血组、右半球和双半球组以中重度损害为主。结论:急性脑血管病引起明显记忆损害,且主要是短时和长时记忆损害,对瞬间记忆影响相对较小。病变部位对记忆损伤程度无明显影响,缺血性卒中病灶数和面积对记忆功能损害影响也无明显差异,但单灶非腔隙性梗死的记忆损害更重。
BACKGROUND: Acute cerebrovascular disease (ACVD) often causes impaired memory function, but the relationship between its subtype, lesion location and clinical features of memory impairment remains unclear. Objective: To study the clinical features of ACVD with memory impairment. Design: Based on diagnosis, a control and standard control retrospective study was set up. Location and Subjects: The study site was Department of Neurology Psychology Laboratory. Daping Hospital, Department of Neurology, admitted from January 1997 to June 2000 57 cases of acute cerebrovascular disease patients, including 19 females, 38 males. Age 37 ~ 91 years old, average 60 years old. The average years of schooling are 10 years. Methods: The “Wechsler Memory Scale” was used to measure the transient, short-term, long-term memory and memory of ACVD patients. The examiner was the first author. MAIN OUTCOME MEASURES: Wechsler memory scale instantaneous, short-term, long-term memory scale subscale and memory business. Results: The total memory of each disease group, short-term and long-term memory scores and memory were significantly lower than the normal control group. Bleeding group and ischemic group, left and right cerebral hemispheres and hemispheres, single-chamber lacunar, single lacunar non-lacunar and multi-lacunar lacunar infarction compared between no significant difference, but a single non-lacunar infarction group, Bleeding group, the right hemisphere and the two hemisphere group to moderate to severe damage. CONCLUSION: Acute cerebrovascular disease causes significant memory impairment, mainly short-term and long-term memory impairment, with relatively little impact on transient memory. The lesion site had no significant effect on the degree of memory impairment. The number and area of ischemic stroke lesions had no significant difference on the impairment of memory function. However, the memory impairment of non-lacunar infarction in single site was more serious.