在白人中血管紧张素转换酶(ACE)基因缺失多态性可能是心肌梗塞的一个重要易患因素。在日本人中尚未进行过这类研究。 方法 对象为42±10岁的100例健康人和59±9岁的178例冠心病(70例心绞痛、108例心肌梗塞)患者。PCR扩增检测ACE插入/缺失多态性。 结果 PCR检测发现有一个490bp片段(Ⅰ等位基因)和一个190bp片段(D等位基 In whites, the absence of the angiotensin-converting enzyme (ACE) gene polymorphism may be an important predisposing factor for myocardial infarction. No such study has been conducted in Japan. Methods Subjects were 100 healthy subjects 42 ± 10 years and 178 patients with coronary heart disease (70 patients with angina and 108 patients with myocardial infarction) 59 ± 9 years of age. PCR amplification to detect ACE insertion / deletion polymorphisms. Results A 490 bp fragment (Ⅰ allele) and a 190 bp fragment (D allele