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目的:初步探讨原发性高血压病与T淋巴细胞及亚群CD28表达之间的相关性。方法:采用三色免疫荧光标记流式细胞术分析原发性高血压病组(36例)和健康对照组(48例)外周血CD3~+、CD4~+、CD8~+T细胞及CD4~+、CD8~+T细胞CD28表达水平,并对原发性高血压病的危险因素进行分析。结果:年龄、性别、CD4~+CD28~-T细胞亚群(P=0.089,OR=1.22,90%CI:1.01～1.48)为原发性高血压病的危险因素。结论:CD4~+CD28~-T细胞亚群为原发性高血压病一个危险因素,且可能参与了发病过程。
Objective: To investigate the relationship between essential hypertension and T lymphocyte and subpopulation CD28 expression. Methods: The expressions of CD3 +, CD4 +, CD8 + T cells in peripheral blood and CD4 ~ + T cells in peripheral blood of patients with essential hypertension (36 cases) and healthy controls (48 cases) +, CD8 ~ + T cells CD28 expression levels, and analysis of risk factors for essential hypertension. Results: Age, sex, CD4 ~ + CD28 ~ -T cell subsets (P = 0.089, OR = 1.22,90% CI: 1.01-1.48) were the risk factors of essential hypertension. Conclusion: CD4 ~ + CD28 ~ -T cell subsets are a risk factor of essential hypertension and may be involved in the pathogenesis.