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目的:观察心脉康对动脉粥样硬化(AS)家兔血脂代谢和丙二醛(MDA)、超氧化物歧化酶(SOD)的影响,并探讨其预防AS形成可能的作用机制。方法:将70只普通级新西兰兔随机分为空白组、模型组、心脉康预防组、血脂康预防组、心脉康治疗组和血脂康治疗组,高脂饲料喂饲复制AS模型;12周后测定各组家兔血清胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、SOD、MDA。结果:与模型组比较,心脉康预防组和治疗组TG、TC、LDL含量明显下降(P<0.01),心脉康治疗组MDA含量有下降趋势,但无显著性意义(P>0.05),SOD活性明显升高(P<0.05)。结论:心脉康有明显的抗家兔AS形成的作用,可能与其降低血脂、减轻过氧化损伤等因素有关。
Objective: To observe the effects of Xinmaikang on blood lipid metabolism, malondialdehyde (MDA) and superoxide dismutase (SOD) in atherosclerotic rabbits and to explore its possible mechanism of preventing AS formation. Methods: Seventy-seven New Zealand white rabbits were randomly divided into blank group, model group, Xinmaikang prevention group, Xuezhikang prevention group, Xinmaikang treatment group and Xuezhikang treatment group, and high fat diet fed AS model. Serum cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), SOD and MDA were measured in the rabbits in each group. Results: Compared with the model group, the content of TG, TC and LDL in the Xinmaikang prevention group and the treatment group were significantly decreased (P <0.01), while the MDA content in the Xinmaikang treatment group was decreased, but no significant difference (P> 0.05) , SOD activity was significantly increased (P <0.05). Conclusion: The effect of Xinmaikang on the formation of AS in rabbits may be related to the reduction of blood lipids and the reduction of the injury of peroxidation.