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目的:观察卵巢过度刺激综合征(OHSS)患者行全胚冷冻后,择期进行解冻移植(FET)的临床结局,探讨其临床应用价值。方法:回顾性分析从2014-01-2014-12在我院生殖中心行常规体外受精-胚胎移植(IVFET)助孕治疗且有OHSS高风险的患者共187例,根据其移植时机分为为2组:A组为新鲜囊胚移植组72例;B组为全囊胚冷冻后择期解冻移植组115例。比较2组间的临床特征、促排卵情况、胚胎情况、妊娠结局及OHSS发生情况。结果:2组间的临床特征、促排卵情况、胚胎情况、早期流产率差异均无统计学意义。而2组间的临床妊娠率(45.8%vs.72.2%)和种植率(30.8%vs.52.8%)差异均有统计学意义(P<0.05)。OHSS发生率A组为8.33%,B组为0.87%,2组间的差异有统计学意义(P<0.05)。结论:OHSS患者冷冻全部囊胚后择期行解冻胚胎移植可以获得良好的妊娠结局,是一项安全的预防卵巢过度刺激综合征的临床应用方案。
OBJECTIVE: To observe the clinical outcome of thawed embryos (FET) after ovulation hyperstimulation syndrome (OHSS) patients undergo whole-cell cryopreservation and to explore its clinical value. METHODS: A total of 187 patients with high-risk OHSS who underwent routine IVF-IVF from 2014-01 to 2014-12 in our hospital were retrospectively analyzed. The patients were divided into two groups according to their timing of transplantation Group A: 72 fresh blastocysts transplantation group; Group B: 115 frozen thawed group. The clinical features, ovulation induction, embryo status, pregnancy outcome and OHSS were compared between the two groups. Results: There were no significant differences in clinical features, ovulation induction, embryo status and early abortion rate between the two groups. The clinical pregnancy rate (45.8% vs.72.2%) and the implantation rate (30.8% vs.52.8%) were significantly different between the two groups (P <0.05). The incidence of OHSS in group A was 8.33% and in group B was 0.87%. The difference between the two groups was statistically significant (P <0.05). Conclusion: It is a safe clinical strategy to prevent ovarian hyperstimulation syndrome in OHSS patients after all frozen blastocysts are electively thawed and embryo transfer can be obtained.