狼疮性肾炎(LN)在系统性红斑狼疮(SLE)发病中较受重视,对其发病机理的研究一直是免疫学领域中的重要课题。虽然免疫复合物(IC)在LN致病过程中的研究已取得了很大进展,但仍不能对LN发病的免疫学机理作出满意地解释。通过动物模型的建立,各种单克隆抗体的制备以及实验新技术的开展,对SLE多种自身抗体、IC与肾脏损害的关系也逐渐明确。现将自身抗体在LN致病的研究进展概述如下。 Lupus nephritis (LN) in the pathogenesis of systemic lupus erythematosus (SLE) more attention, the pathogenesis of the study has been an important issue in the field of immunology. Although great progress has been made in the research of immune complex (IC) in LN pathogenesis, the immunological mechanism of LN can not be satisfactorily explained. Through the establishment of animal models, the preparation of various monoclonal antibodies and the development of new experimental techniques, the relationship between SLE multiple autoantibodies and IC and kidney damage has gradually become clear. The progress of autoantibodies on the pathogenesis of LN is summarized as follows.