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[目的]探讨B超引导下射频消融(RFA)联合肝动脉介入热灌注化疗栓塞治疗原发性肝癌的临床价值。[方法]36例原发性肝癌患者随机分为联合组(18例)和对照组(18例),联合组采取肝动脉介入热灌注化疗栓塞联合RFA治疗,对照组仅行RFA治疗。治疗后通过影像学进行疗效评价。[结果]联合组和对照组临床治疗有效率分别为72.2%和44.4%(P=0.024)。RFA治疗的主要不良反应为肝区疼痛或上腹部不适,对照组1例患者治疗后4d因上消化道大出血死亡。肝动脉介入热灌注化疗的主要不良反应为发热、恶心呕吐、肝区疼痛等,对症处理后均好转。[结论]肝动脉介入热灌注化疗栓塞联合RFA是原发性肝癌的一种有效治疗方法。
[Objective] To investigate the clinical value of radiofrequency ablation (RFA) combined with transcatheter arterial chemoembolization in the treatment of primary liver cancer under ultrasound guided. [Method] Thirty-six patients with primary liver cancer were randomly divided into the combined group (18 cases) and the control group (18 cases). The combined group received hepatic arterial infusion chemotherapy and embolization combined with RFA. The control group received RFA only. After treatment by imaging evaluation of efficacy. [Results] The effective rates of clinical treatment in combined group and control group were 72.2% and 44.4%, respectively (P = 0.024). The main side effects of RFA were liver pain or upper abdominal discomfort. One patient in the control group died of upper gastrointestinal bleeding 4 days after treatment. The main adverse reactions of hepatic artery interventional hyperthermic chemotherapy were fever, nausea and vomiting, pain in the liver area and so on after symptomatic treatment. [Conclusion] Hepatic artery interventional thermochemoembolization combined with RFA is an effective treatment for primary liver cancer.