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(一)家犬精子生成的抑制、恢复及毒性观察实验共用成年家犬12只,分为4组(每组3只);1～3组分别置于二氟二溴甲烷浓度为90、60、30毫克/升的相对密闭箱内,每天暴露1次,每次1小时,连续给药11周,停药后继续观察11周。第四组为对照组,给药11周结束及停药一定时间,取动物睾丸及付睾作组织学标本供镜检。在给药期间,检查了肝、肾功能;进行了红细胞及白细胞的计数;对第一组的个别动物精液精子进行了计数。在停药的前后,对睾丸的大小作
(1) Inhibition, recovery and toxicity observation of spermatogenesis in domestic dogs 12 adult dogs were divided into 4 groups (3 in each group); 1 to 3 groups were placed in difluorobisbromomethane concentration of 90,60, 30 mg / L in airtight box, exposed once a day, every 1 hour, continuous administration for 11 weeks, continue to observe after stopping 11 weeks. The fourth group for the control group, the end of 11 weeks of administration and withdrawal for a certain period of time, animals were taken testis and testis for histological specimens for microscopic examination. Liver and kidney functions were examined during dosing; erythrocytes and leukocytes were counted; semen sperm from individual animals in the first group were counted. Before and after withdrawal, the size of the testes