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[目的]研究二硫化碳(CS2)暴露对作业工人血糖(glucose,GLU)、总胆固醇(total cholesterol,TCHO)和三酰甘油(triglyceride,TG)检出水平的影响,并提出职业健康监护行动水平的建议。[方法]收集某化纤厂2004—2011年间工作场所CS2浓度或作业工人个体接触CS2浓度的检测资料,对该化纤厂3 456名接触CS2的作业工人分别进行GLU、TCHO和TG水平的检查。[结果]该化纤厂作业工人接触CS2的8 h时间加权平均浓度为0.2~41.0 mg/m3,几何均数为2.38 mg/m3。其中1 758名作业工人接触CS2的浓度在0.2~2.5 mg/m3之间(A组);653名作业工人接触CS2的浓度在2.6~4.8 mg/m3之间(B组);1 045名作业工人接触CS2的浓度在5.1~41.0 mg/m3之间(C组)。男性C浓度组高TG检出率高于A、B两浓度组,差异有统计学意义(P<0.05);A、B浓度组之间差异无统计学意义(P>0.05)。男性高GLU、高TCHO检出率及女性高GLU、高TCHO和高TG检出率在不同浓度组中差异均无统计学意义(P>0.05)。各年龄段C浓度组高TG检出率高于A、B两浓度组;A、B浓度组间差异无统计学意义(P>0.05)。不同浓度组间高GLU和高TCHO检出率差异无统计学意义(P>0.05)。男性不同累积接触量组间高TG检出率差异有统计学意义(P<0.01);高GLU和高TCHO检出率差异无统计学意义(P>0.05)。女性不同累积接触量组间高GLU、高TCHO和高TG检出率差异无统计学意义(P>0.05)。[结论]男性作业工人接触CS2浓度>5 mg/m3或累积接触量>50 mg/(m3·年)时,可使高TG检出率明显升高。在对CS2作业工人进行职业健康监护时,宜执行CS2时间加权平均浓度为2.5 mg/m3(职业接触限值的1/2)的行动水平,并加强对累积接触量>50 mg/(m3·年)的作业工人的健康检查。
[Objective] To investigate the effects of carbon disulfide (CS2) exposure on workers’ blood glucose (GLU), total cholesterol (TCHO) and triglyceride (TG) levels and to propose occupational health monitoring Suggest. [Method] The test data of concentration of CS2 in workplace or individual exposed to CS2 concentration in a chemical fiber factory from 2004 to 2011 were collected. The level of GLU, TCHO and TG in 3 456 CS2 exposed workers in this chemical fiber factory were examined. [Result] The weighted average concentration of CS2 exposed workers to CS2 was 0.2 ~ 41.0 mg / m3 for 8 hours, and the geometric mean was 2.38 mg / m3. Of these, 1 758 workers exposed to CS2 had a concentration of 0.2-2.5 mg / m3 (group A); 653 workers exposed to CS2 had a concentration of 2.6-4.8 mg / m3 (group B); 1,045 operations Workers exposed to CS2 concentrations between 5.1 ~ 41.0 mg / m3 (C group). The detection rate of high TG in male C concentration group was higher than that in A and B concentration group, the difference was statistically significant (P <0.05). There was no significant difference between A and B concentration group (P> 0.05). There were no significant differences in the detection rates of male high GLU, high TCHO and female high GLU, high TCHO and high TG in different concentration groups (P> 0.05). The detection rate of high TG in C concentration group was higher than that of A and B concentration groups in all age groups. There was no significant difference between A and B concentration groups (P> 0.05). There was no significant difference in the detection rates of high GLU and high TCHO between different concentration groups (P> 0.05). There was significant difference in the detection rate of high TG between groups with different cumulative exposures (P <0.01). There was no significant difference in the detection rates of high GLU and high TCHO (P> 0.05). There were no significant differences in the detection rates of high GLU, high TCHO and high TG among different cumulative exposure groups (P> 0.05). [Conclusion] The detection rate of high TG can be significantly increased when male workers exposed to CS2> 5 mg / m3 or cumulative exposure> 50 mg / (m3 · year). In occupational health monitoring of CS2 workers, the time-weighted average CS2 concentration of 2.5 mg / m3 (1/2 of the occupational exposure limit) should be implemented and the cumulative exposure to> 50 mg / (m3 · Year) of the workers in the health examination.