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近年来,人们提供的研究资料表明,标记突变的各项生物学指标(如染色体畸变率、淋巴细胞微核率等)与年龄呈函数关系,支持机体衰老的突变假说.认为突变是基于随年龄的增长,未修复的DNA损伤的蓄积和/或随年龄增长对DNA损伤的修复能力降低所致.作者为进一步阐明上述问题,观察比较了0～82岁的新生儿、医务工作者、献血员和老年人组淋巴细胞微核的基础水平.又比较研究了DNA的损伤因子-X线照射及丝裂霉素C(MC)处理淋巴细胞后的年轻人
In recent years, research data provided by people indicate that the various biological indicators (such as chromosome aberration rate, lymphocyte micronucleus rate, etc.) of the marker mutation are functionally related to age and support the mutation hypothesis of body senescence. , The accumulation of uncorrected DNA damage and / or the diminished ability to repair DNA damage with increasing age. To further elucidate the above problems, we compared the effects of newborns aged 0-82 years, medical workers, blood donors And the basic level of lymphocyte micronucleus in the elderly group.A comparative study of DNA damage factor-X-ray irradiation and mitomycin C (MC) treatment of young people after lymphocytes