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目的 :研究血、尿α1 微球蛋白 (MG)在晚期肺癌化疗中对肾功能评价的临床应用价值。方法 :将 80例晚期肺癌患者随机分为 2组 ,小剂量顺铂组 40例 (DDP 6 0mg/m2 ) ,大剂量顺铂组 40例 (DDP 10 0mg/m2 ) ,分别在化疗前、化疗后 2 4— 48h和 3周时测定血、尿α1 MG及同期测得的血尿素氮 (BUN)、肌酐 (Cr)进行分析比较。结果 :化疗前、化疗后 2 4— 48h小剂量顺铂组尿α1 MG明显升高 (P <0 0 5 ) ,而大剂量顺铂组血、尿α1 MG明显升高 (P <0 0 5 ) ,3周后复查均恢复正常。BUN、Cr在化疗前、化疗后 2 4— 48h和 3周时均无明显差异 (P >0 0 5 )。结论 :联合测定血、尿α1 MG能够较早地反映轻微肾小球、肾小管功能损害 ,且较血BUN、Cr更灵敏
Objective: To study the clinical value of blood and urinary α1 microglobulin (MG) in the evaluation of renal function in advanced lung cancer chemotherapy. METHODS: Eighty patients with advanced lung cancer were randomly divided into two groups. 40 patients in the low-dose cisplatin group (DDP 60 mg/m2) and 40 patients in the high-dose cisplatin group (DDP 100 mg/m2), before and after chemotherapy The blood and urine α1 MG and blood urea nitrogen (BUN) and creatinine (Cr) measured at the same time were analyzed and compared at 24 to 48 and 3 weeks later. Results: Urinary α1 MG was significantly increased in the low-dose cisplatin group before and after chemotherapy (P<0.05), while α1 MG in the high-dose cisplatin group was significantly higher (P<0 0 5). ) After 3 weeks, the review was normal. There was no significant difference in BUN and Cr before chemotherapy and 24 to 48 and 3 weeks after chemotherapy (P > 0 05). Conclusion : The joint determination of blood and urine α1 MG can reflect the glomerular and tubular dysfunction earlier, and it is more sensitive than blood BUN and Cr.