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目的:通过比较阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患儿和健康儿童的中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)的差异,探讨NLR和PLR与儿童OSAHS严重程度的关系。方法:选取122例OSAHS患儿,根据睡眠期呼吸暂停低通气指数(AHI)及最低动脉血氧饱和度(LSaO2)情况分为3组,分别为轻度OSAHS组41例、中度OSAHS组41例和重度OSAHS组40例,同时选取正常对照组40例,比较各组之间NLR、PLR的差异。结果:NLR的组间比较显示重度OSAHS组(1.57±0.58)显著高于正常对照组(0.98±0.22)、轻度OSAHS组(1.24±0.47)、中度OSAHS组(1.36±0.46),差异有统计学意义(P<0.05)。PLR的组间比较显示正常对照组(95.65±2.50)、轻度OSAHS组(98.16±2.13)、中度OSAHS组(103.52±22.37)、重度OSAHS组(100.47±30.60)4组组间差异无统计学意义(P>0.05)。NLR与睡眠期AHI是呈正相关的(r=0.385,P=0.000),同时LSaO_2与AHI呈负相关(r=-0.686,P=0.000)。结论:NLR可作为评估OSAHS严重程度的指标,而PLR无明显临床意义。
Objective: To compare the difference of neutrophil / lymphocyte ratio (NLR) and platelet / lymphocyte ratio (PLR) between children with obstructive sleep apnea-hypopnea syndrome (OSAHS) and healthy children, Children OSAHS severity of the relationship. Methods: A total of 122 OSAHS children were enrolled and divided into 3 groups according to sleep apnea-hypopnea index (AHI) and minimum arterial oxygen saturation (LSaO2): 41 in mild OSAHS group and 41 in moderate OSAHS group Cases and severe OSAHS group of 40 patients, while 40 cases of normal control group were selected to compare the difference between the groups NLR, PLR. RESULTS: Comparisons between NLR groups showed that the OSAHS group (1.57 ± 0.58) was significantly higher than that of the normal OSAHS group (0.98 ± 0.22), mild OSAHS group (1.24 ± 0.47) and moderate OSAHS group (1.36 ± 0.46) Statistical significance (P <0.05). PLR between groups showed no statistically significant difference between the four groups of normal control group (95.65 ± 2.50), mild OSAHS group (98.16 ± 2.13), moderate OSAHS group (103.52 ± 22.37), severe OSAHS group (100.47 ± 30.60) Significance (P> 0.05). There was a positive correlation between NLR and AHI during sleep (r = 0.385, P = 0.000), while LSaO_2 was negatively correlated with AHI (r = -0.686, P = 0.000). Conclusion: NLR can be used as an index to evaluate the severity of OSAHS, but PLR has no obvious clinical significance.