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关于急性氟中毒患者的心血管改变及氟元素对心脏生理的影响,早有研究。国内外文献报道,急性氟中毒时,心血管系统损害严重,是造成死亡的原因之一;而慢性氟中毒,尤其是地方性氟中毒对心血管的影响,资料较少,且意见不一。为此,我们于1981年3～4月对365例地方性氟中毒患者作了心电图检查,并与非病区191例正常人心电图资料作对照观察。现报道如下。病例选择及观察方法一、检查对象:地方性氟中毒病区选择安康县恒口公社红五大队,水氟含量为0.35～6.10ppm,氟斑牙患病率在80%以上,为饮水性氟中毒病区。对365例患者作了心电图检查,其分型分度及诊断标准根据“北方地方性氟中毒防治标准试行草案”。对照组地区选择邻近的红四大队,水氟含量为0.15～0.22ppm,其它环境因素与病区相当,随机检查191人。所有被检者均排除了风湿性心脏病,高血压性心脏病,冠心病,肺源性心脏病及心肌病等器质性心脏病变。
Acute fluorosis in patients with cardiovascular changes and fluoride on cardiac physiology, has long been studied. Domestic and foreign literature reports, acute fluorosis, the cardiovascular system damage is serious, is one of the causes of death; and chronic fluorosis, especially the impact of endemic fluorosis on cardiovascular, less data, and different opinions. To this end, we conducted 365 cases of endemic fluorosis in patients with electrocardiogram from March to April 1981, and compared with the ECG data of 191 normal subjects in non-endemic area. Report as follows now. Case selection and observation methods First, the examination object: endemic fluorosis area selection Ankang County Hengkou commune red five brigades, water fluoride content of 0.35 ~ 6.10ppm, the prevalence of dental fluorosis more than 80% for drinking water fluoride Poison ward. Electrocardiogram was performed on 365 patients. The sub-classification and diagnostic criteria were based on the “Draft Standard for Prevention and Control of Endemic Fluorosis in North China.” In the control group, the adjacent Red Fourth Battalion was selected. The water fluoride content was 0.15-0.22ppm. The other environmental factors were similar to the ward, and 191 were randomized. All subjects were ruled out rheumatic heart disease, hypertensive heart disease, coronary heart disease, pulmonary heart disease and cardiomyopathy and other organic heart disease.