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目的:观察香砂养胃丸配合三联疗法治疗幽门螺杆菌(Hp)阳性消化性溃疡的临床疗效。方法:将108例Hp阳性消化性溃疡患者随机分为A、B两组各54例,A组予香砂养胃丸5g+奥美拉唑20mg+阿奇霉素500mg+左氧氟沙星200mg,B组给予奥美拉唑20mg+阿奇霉素500mg+左氧氟沙星200mg,疗程均为4周。记录临床症状缓解时间,计算Hp根除率和临床疗效,记录溃疡复发情况。结果:一个疗程后,A组患者上腹痛、腹胀和嗳气改善时间较B组均明显缩短(P<0.05)。A组显效率和Hp根除率明显高于B组(P<0.05),而两组总有效率相近(P>0.05)。一年后溃疡复发率也明显低于B组(P<0.05)。结论:香砂养胃丸配合三联疗法治疗Hp阳性消化性溃疡,具有根除率高、缓解症状快、复发率低等优点,值得临床推广。
Objective: To observe the clinical efficacy of Xiangsha Yangwei Pill combined with triple therapy in treating Hp positive peptic ulcer. Methods: A total of 108 patients with Hp-positive peptic ulcer were randomly divided into two groups (A and B), 54 cases in each group. The patients in group A received Xiangshayangwei Pills 5g plus omeprazole 20mg plus azithromycin 500mg plus levofloxacin 200mg, while those in group B received omeprazole 20mg + Azithromycin 500mg + levofloxacin 200mg, treatment were 4 weeks. Record the clinical symptom relief time, calculate Hp eradication rate and clinical curative effect, record the ulcer recurrence. Results: After a course of treatment, the improvement time of abdominal pain, bloating and belching in group A was significantly shorter than that in group B (P <0.05). The markedly effective rate and Hp eradication rate in group A were significantly higher than those in group B (P <0.05), while the total effective rate was similar in both groups (P> 0.05). The recurrence rate of ulcer in one year was also significantly lower than that in group B (P <0.05). Conclusion: Xiangshayangwei pills combined with triple therapy for Hp-positive peptic ulcer has the advantages of high eradication rate, quick response to symptoms and low recurrence rate, which is worthy of clinical promotion.