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异烟肼(INH)加利福平(RFP)9个月疗法对敏感菌引起的肺结核非常有效,且对所有肺外结核包括结核性胸膜炎伴或不伴有肺内病变者也均有效。已证明,如果细菌含量少,即治疗前痰涂片检菌≥3次阴性,而培养阳性者,疗程可缩短至6个月。结核性胸膜炎时由于涂片检菌多为阴性,培养也少有阳性,故也属于含菌量少者,推测也可将疗程缩短至6个月。为此,自1980～1990年间进行以下临床实验。对象和方法共收治符合条件的结核性胸水患者198(男128,女70)例,平均年龄62.6(18～97)岁,其中59例(30％)具有结核病易感因素;92例同时伴有肺浸润,50％患者痰培养阳性。给药方法:INH 300mg加RFP 600mg,每日1次,治疗1个月。后用INH
Isoniazid (INH) 9-month therapy with rifampicin (RFP) is very effective against tuberculosis caused by susceptible bacteria and is also effective against all extra-pulmonary tuberculosis, including tuberculous pleurisy with or without intrapulmonary lesions. Has proved that if the bacterial content is less, that is, sputum smear 3 times negative before treatment, and cultured positive, treatment can be shortened to 6 months. Tuberculous pleurisy due to smear more negative bacteria, culture is also rarely positive, it also belongs to the less bacteria, it is speculated that the treatment can be shortened to 6 months. To this end, from 1980 to 1990 the following clinical trials. Subjects and Methods A total of 198 patients (male 128, female 70) with tuberculous pleural effusion were eligible for treatment. The mean age was 62.6 (18-97) years old. Of these, 59 (30%) had tuberculosis susceptibility factors; 92 Pulmonary infiltration, sputum culture positive in 50% of patients. Methods of administration: INH 300mg plus RFP 600mg, 1 day, treatment 1 month. After using INH