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目的:观察米索前列腺醇片阴道内塞药后联合丙泊酚,芬太尼静脉麻醉在无痛人工流产中的有效性及安全性。方法:观察200例要求行无痛人工流产的初孕妇女,随机分为观察组和对照组各100例。A组采用米索前列腺醇片剂阴道给药后人流中采用丙泊酚与芬太尼静脉麻醉。B组采用丙泊酚与芬太尼单纯静脉麻醉。观察2组血压,心率,呼吸,血氧饱和度,手术时间及丙泊酚追加量,宫颈松弛度,镇痛效果,清醒时间及人工流产综合征等指标。结果:2组术前,术中,术后血压、心率、血氧饱和度无明显变化,而对照组的呼吸术中有不同程度的影响,丙泊酚加前列腺醇组的宫颈松弛度好,手术时间短,丙泊酚用量少,患者苏醒快,镇痛效果好,手术并发症少。结论:米索前列腺醇联合丙泊酚.芬太尼静脉全身麻醉镇痛安全可靠,操作简便,适合于门诊无痛人工流产的手术。
OBJECTIVE: To observe the efficacy and safety of misoprostol in the treatment of painless induced abortion after intravaginal injection of propofol and fentanyl. Methods: The first trimester women with painless induced abortion were randomly divided into observation group (n = 100) and control group (n = 100). Group A was treated with propofol and fentanyl intravenously after a vaginal administration of misoprostol tablets. B group with propofol and fentanyl intravenous anesthesia. Blood pressure, heart rate, respiration, blood oxygen saturation, operation time and additional propofol, cervical relaxation, analgesic effect, awake time and induced abortion syndrome were observed in two groups. Results: There were no significant changes in blood pressure, heart rate and blood oxygen saturation before, during and after operation in the two groups, while there were different degrees of respiration in the control group. Cervical relaxation was better in propofol plus prostanoid group, Short operative time, less dosage of propofol, rapid recovery of patients, analgesic effect, fewer surgical complications. Conclusion: Misoprostol combined with propofol and fentanyl intravenous general anesthesia analgesia is safe and reliable, easy to operate and suitable for out-patient painless abortion.