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目的探讨E-cadherin蛋白在乳腺导管癌中的表达及意义。方法采用免疫组化方法检测E-cadherin蛋白在53例乳腺浸润性导管癌、25例导管内癌组织和13例乳腺囊性增生病组织中的表达。结果 E-cadherin蛋白在乳腺囊性增生组织、导管内癌及乳腺浸润性导癌中表达逐渐升高,差异有统计学意义。在浸润性导管癌中其表达与病理分级、脉管浸润和腋窝淋巴结转移显著相关。结论 E-cadherin与乳腺浸润性导管癌的发生、发展及淋巴结转移关系密切。
Objective To investigate the expression and significance of E-cadherin protein in breast ductal carcinoma. Methods Immunohistochemical method was used to detect the expression of E-cadherin protein in 53 cases of breast invasive ductal carcinoma, 25 cases of intraductal carcinoma and 13 cases of breast cystic hyperplasia. Results E-cadherin protein expression in cystic hyperplasia of breast, ductal carcinoma and invasive breast cancer gradually increased, the difference was statistically significant. In invasive ductal carcinoma, its expression was significantly associated with pathological grade, vascular invasion and axillary lymph node metastasis. Conclusion E-cadherin is closely related to the occurrence and development of breast invasive ductal carcinoma and lymph node metastasis.