眼科经常使用氨基葡糖苷类(Aminoglycosides)药物治疗或预防细菌感染。此类抗生素具有对耳和肾的毒性作用。通过光学显微镜和电生理检查证实:此药高浓度注入玻璃体,对视网膜组织也具有毒性作用。现已证明在培养的成纤维细胞和肾小管细胞中,这类药物能选择性地聚积在溶酶体中。这种聚积可能是通过神经磷脂酶及磷酸脂酶的活性减低而造成磷脂分解代谢严重紊乱所致。同时,在 Ophthalmics often use aminoglycosides (Aminoglycosides) drugs to treat or prevent bacterial infections. Such antibiotics have toxic effects on the ear and kidney. Through optical microscopy and electrophysiological examination confirmed: high concentration of the drug injected into the vitreous, the retina tissue also has a toxic effect. It has been demonstrated that in cultured fibroblasts and tubular cells, such drugs can selectively accumulate in lysosomes. This accumulation may be due to the activity of phospholipase and phospholipase decreased phospholipid catabolism caused by a serious disorder. At the same time, at