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目的探讨剖宫产术中采用双侧子宫动脉结扎术(Uterine Artery Blocking,UAB)治疗复杂多发子宫肌瘤对女性激素和泌乳素的影响。方法实验组实施双侧UAB,对照组为具备剖宫产指征而无合并症患者,两组各45例。监测术后2h和24h子宫出血量,术前、术后2h和42d雌激素(E2)、孕激素(P)、泌乳素(PRL)水平,术后病率以及子宫复旧情况。结果实验组术后2h和24h子宫出血量少于对照组,差异有统计学意义(P<0.05)。实验组术后病率高于对照组,组间差异有统计学意义(P<0.05)。实验组术前和术后2h外周血E2、P和PRL较对照组高,组间差异有统计学意义(P<0.05),42dE2、P和PRL无统计学差异(P>0.05)。结论 UAB可以减少剖宫产术后子宫出血,抑制子宫肌瘤患者E2、P和PRL的分泌,从而对子宫肌瘤起到治疗作用,同时不影响子宫和卵巢的正常功能。
Objective To investigate the effect of Uterine Artery Blocking (UAB) on hormones and prolactin in women with complicated multiple uterine fibroids during cesarean section. Methods The experimental group was treated with bilateral UAB, while the control group with cesarean indications without complications, two groups of 45 cases. The amount of uterine bleeding at 2h and 24h after operation was measured. The levels of estrogen (E2), progesterone (P), prolactin (PRL), postoperative morbidity and uterine involution were measured before and 2h and 42d after operation. Results The amount of uterine bleeding in experimental group was less than that in control group at 2h and 24h after operation, the difference was statistically significant (P <0.05). The postoperative morbidity of the experimental group was higher than that of the control group, the difference was statistically significant (P <0.05). The levels of E2, P and PRL in peripheral blood of the experimental group were higher than those of the control group before operation and 2h after operation (P <0.05). There was no significant difference between the two groups (P> 0.05). Conclusion UAB can reduce uterine bleeding after cesarean section and inhibit the secretion of E2, P and PRL in patients with uterine fibroids, which can play a therapeutic role in uterine fibroids without affecting the normal function of the uterus and ovary.