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目的观察蛇床子素对肾性高血压诱导大鼠心肌肥厚的治疗作用并探讨其可能的机制。方法采用两肾一夹建立肾性高血压大鼠心肌肥厚模型,用蛇床子素(10 mg/kg和20 mg/kg)治疗4周后检测大鼠血压、心质量指数及心肌超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)、丙二醛(MDA)含量、血糖及血和心肌游离脂肪酸(FFA)含量。用光镜检查心肌组织的病理学变化。结果蛇床子素可降低心肌肥厚大鼠的血压、心质量指数、心肌MDA含量和血及心肌FFA含量,尤其是大剂量组的作用更为明显(P<0.05或P<0.01),同时蛇床子素也能明显升高心肌SOD和GSH-P含量及血糖水平(P<0.05或P<0.01)。光镜检查结果显示蛇床子素组大鼠心肌肥厚程度减轻。结论蛇床子素能治疗肾性高血压诱导的大鼠心肌肥厚,其主要机制可能与抑制氧化应激和改善心肌能量代谢有关。
Objective To investigate the therapeutic effect of osthole on renal hypertrophy-induced cardiac hypertrophy in rats and its possible mechanism. Methods The model of renal hypertrophy was established by using two kidneys and one clip. After 4 weeks of treatment with osthole (10 mg / kg and 20 mg / kg), the blood pressure, cardiac mass index and myocardial superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), malondialdehyde (MDA), blood glucose and free fatty acids (FFA) in blood and myocardium. Using light microscopy to check the pathological changes of myocardial tissue. Results Osthole could decrease the blood pressure, cardiac mass index, myocardial MDA content and the content of FFA in blood and myocardium in hypertrophied rats, especially in high-dose group (P <0.05 or P <0.01) Su also significantly increased myocardial SOD and GSH-P levels and blood glucose levels (P <0.05 or P <0.01). Light microscopy results showed that the osthole group rats myocardial hypertrophy reduced. Conclusion Osthole can treat renal hypertrophy induced rat cardiac hypertrophy, the main mechanism may be related to inhibiting oxidative stress and improving myocardial energy metabolism.