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目的:探讨肝肿瘤患者围手术期间伴有出凝血功能障碍时科学合理进行血制品输注的方法。方法:120例分为血小板和冷沉淀联合输注组51例(联合组)和单独使用血小板组69例(对照组),输注前后进行血小板计数(PLT)、凝血酶原时间(PT)、活化部分活化凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(Fib)、DD二聚体(D-Dimer)的检测并观察临床疗效。结果:血小板和冷沉淀联合输注组患者PT、TT明显缩短;Fib(纤维蛋白原)明显增加;PLT明显增加,D-Dimer显著降低,而单独输注血小板组除了血小板数量增加外,其余指标改善不明显。联合输注组的临床症状改善情况更明显。结论:血小板和冷沉淀的联合输注能有效改善肝肿瘤患者围术期的凝血功能障碍,保障患者围术期的治疗安全。
Objective: To investigate the method of transfusion of blood products scientifically and rationally during the perioperative period of patients with liver cancer who have coagulation dysfunction. Methods: One hundred and twenty-one patients were divided into platelet and cryoprecipitate combined with infusion group, 51 patients in combination group and 69 patients in control group. PLT, PT, Activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (Fib), DD dimer (D-Dimer) of the test and observe the clinical efficacy. Results: The PT and TT were significantly shortened in patients with combination of platelet and cryoprecipitate, Fib (fibrinogen) was significantly increased, PLT was significantly increased, D-Dimer was significantly decreased, while platelet alone infusion group in addition to an increase in the number of platelets, the remaining indicators Improvement is not obvious. The clinical symptoms of the combination infusion group improved more significantly. Conclusion: The combined infusion of platelet and cryoprecipitate can effectively improve the perioperative coagulation dysfunction in patients with liver cancer and ensure the perioperative safety of the patients.