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目的 探讨增殖细胞核抗原 (proliferatingcellnuclearantigen ,PCNA)在乳腺浸润性导管癌中表达与TNM分期及预后的关系。方法 应用免疫组织化学ABC法检测 10 0例乳腺浸润性导管癌PCNA的表达。结果 死亡组PCNA指数 (PI) (5 6 .5 %± 2 6 .5 4% )明显高于存活组PI(31.5 %± 2 6 .88% ,P <0 .0 1)。结论 PCNA表达可能是反映乳腺癌生物学行为及预后的重要指标。
Objective To investigate the relationship between the expression of proliferating cell nuclear antigen (PCNA) in breast invasive ductal carcinoma and TNM staging and prognosis. Methods The expression of PCNA in invasive ductal carcinoma of the breast was detected by immunohistochemical ABC method. Results The PCNA index (PI) in the death group (56.5% ± 26.5%) was significantly higher than that in the survival group (31.5 % ± 26.88%, P < 0.01). Conclusion The expression of PCNA may be an important indicator reflecting the biological behavior and prognosis of breast cancer.