论文部分内容阅读
一、常用化疗方案 1.单一用药 (一)呋喃氟脲嘧啶(FT-207)本药作用原理同氟脲嘧啶(5-FU),其特点是毒性低,口服或直肠给药吸收良好,化疗指数为5-FU的两倍。口服每日600～800mg,分3～4次,总量20～40g,有效率20％。副反应有食欲不振、恶心、呕吐。引起白细胞与血小板减少者不及10％。直肠给药每剂500mg,每日500～1000mg,总量20～60g,有效率26.0～33.3％,稍高于口服。消化道副反应少,血象影响轻。 (二)优福定(UFT)UFT每片含FT-207 50mg及尿嘧啶(Uracil)112mg。Uracil本身无抗癌作用,但可阻碍5-FU的分解代谢,使FT-207吸收后生成5-FU的浓度提高,不增加毒性。每日口服3次,每次
First, the commonly used chemotherapy program 1. Single drug (a) furan fluorouracil (FT-207) The principle of the drug with fluorouracil (5-FU), which is characterized by low toxicity, oral or rectal absorption is good, chemotherapy The index is twice that of 5-FU. Oral daily 600 ~ 800mg, divided 3 ~ 4 times, the total 20 ~ 40g, an effective rate of 20%. Side effects are loss of appetite, nausea, and vomiting. Less than 10% of patients cause leukocytopenia and thrombocytopenia. Rectal administration of 500mg per dose, daily 500 ~ 1000mg, total 20 ~ 60g, effective rate of 26.0 ~ 33.3%, slightly higher than oral. Less side effects of the digestive tract, and less influence of blood. (b) UFT UFT contains 50 mg of FT-207 and 112 mg of Uracil. Uracil itself has no anticancer effect, but it can block the catabolism of 5-FU and increase the concentration of 5-FU produced by FT-207 absorption without increasing toxicity. Oral 3 times a day, every time