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目的:研究息斯敏(阿司咪唑)对小鼠的致心律失常作用,了解其致心律失常的类型,推测其致心律失常的机理,为临床用药提供实验依据。方法:小鼠灌胃息斯敏,记录30min、60min、90min、120min、150min、180min小鼠心电图的变化。结果:息斯敏可引起多数小鼠出现缓慢性心律失常,心电图表现为心率减慢,P-R间期和Q-T间期延长,随剂量增加,甚至可引起完全性房室传导阻滞和窦性停搏。少数情况也会出现窦性、室性心动过速等快速性心律失常。结论:息斯敏可引起小鼠多型性心律失常,以缓慢性心律失常为主,快速心律失常少见,并随剂量增加,死亡率提高。
OBJECTIVE: To study the effect of Astemizole on arrhythmia in mice, understand the type of arrhythmia induced, and to infer the mechanism of arrhythmia, so as to provide experimental evidence for clinical use. Methods: Mice were given astemizole and the change of electrocardiogram in mice was recorded at 30min, 60min, 90min, 120min, 150min, 180min. Results: Astemizole induced bradyarrhythmia in most mice. The ECG showed a slowing of heart rate, prolongation of PR interval and QT interval. With dose increasing, even complete atrioventricular block and sinus arrest Stroke A few cases also appear sinus, ventricular tachycardia and other tachyarrhythmia. Conclusion: Astemizumab can induce polymorphism of arrhythmia in mice. The main symptoms are bradyarrhythmia, tachyarrhythmia is rare, and mortality increases with dose increase.