酰基转移反应在许多生物学或化学过程中都起着十分重要的作用。氨酰tRNA合成酶在蛋白质生物合成中起关键作用。它催化tRNA的终端腺苷上2′,3′-二醇的酯化反应。伯克利化学系的Schultz小组最近提出这样一个问题,能否产生催化这类反应的抗体。这样的抗体也许会加速tRNA与新氨基酸的氨酰化,可用于蛋白质的生物合成研究。他们发现,针对磷酸二酯过渡态类似物产生的一种 Acyl transfer reactions play a very important role in many biological or chemical processes. Aminoacyl tRNA synthetase plays a key role in protein biosynthesis. It catalyzes the esterification of 2 ’, 3’-diols on the terminal adenosine of tRNAs. The Schultz team at the Berkeley Chemistry Department recently asked the question of whether antibodies can be produced that catalyze such reactions. Such antibodies may accelerate the aminoacylation of tRNAs with new amino acids and may be used in protein biosynthesis studies. They found that one against the phosphodiester transition state analogs