论文部分内容阅读
目的探讨乳腺癌前哨淋巴结转移(SLNM)与血管内皮细胞生长因子(VEGF)、分子分型的关系。方法搜集手术病理证实的乳腺癌42例,其中SLNM 22例为研究组,无淋巴结转移20例为对照组,术前行1.5 T Aurora乳腺专用磁共振动态增强扫描,术后标本进行VEGF-c及ER,PR,Her-2免疫组织化学染色,比较两组VEGF-c评分及分子分型的差异。结果研究组VEGF-c评分≥2分比例高于对照组(P=0.005),Her-2阳性型+三阴型的比例高于对照组(P=0.043)。结论乳腺癌SLNM与VEGF-c、分子分型关系较为密切,VEGF-c高表达、Her-2阳性型+三阴型更容易发生前哨淋巴结转移。
Objective To investigate the relationship between SLNM and vascular endothelial growth factor (VEGF) and molecular typing in breast cancer. Methods Forty-two cases of breast cancer confirmed by pathology were collected. Twenty-two cases of SLNM were study group, 20 cases without lymph node metastasis as control group. The MRI scan of 1.5 T Aurora breast enhanced MRI was performed before operation. VEGF- ER, PR, Her-2 immunohistochemical staining, VEGF-C score and molecular classification differences between the two groups were compared. Results The ratio of VEGF-c score≥2 was higher in the study group than in the control group (P = 0.005). The proportion of Her-2 positive type and triple-negative type was higher in the study group than in the control group (P = 0.043). Conclusion The relationship between SLNM and VEGF-c in breast cancer is closely related to the molecular typing. VEGF-c is highly expressed, and her-2 positive and triple negative are more prone to sentinel lymph node metastasis.