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目的探讨长托宁联合大黄治疗重度有机磷农药中毒的临床效果。方法急性重度有机磷农药中毒患者40例随机分为长托宁联合大黄组(A组)和长托宁联合甘露醇组(B组),每组20例。观察两组治疗后胆碱酯酶恢复时间、住院天数、症状消失时间、反跳率、中间综合征、治愈率。结果与B组比较,A组胆碱酯酶恢复时间、住院天数、中间综合征、反跳率明显降低,P<0.05,治愈率明显升高,P<0.05。结论长托宁联合大黄是治疗重度有机磷农药中毒的理想药物组合。
Objective To investigate the clinical effect of combination of penehyclidine hydrochloride and rhubarb on severe organophosphorus pesticide poisoning. Methods Forty patients with acute severe organophosphorus pesticide poisoning were randomly divided into two groups: 20 cases in each group. After treatment, the cholinesterase recovery time, hospitalization days, symptom disappearance time, rebound rate, intermediate syndrome and cure rate were observed. Results Compared with group B, the recovery time of cholinesterase, length of stay in hospital, intermediate syndrome and rebound rate were significantly decreased in group A (P <0.05). The cure rate was significantly increased, P <0.05. Conclusions Penehyclidine and rhubarb are the ideal combination of drugs for the treatment of severe organophosphorus pesticide poisoning.