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目的 :探讨人类白细胞抗原 (HLA)的DRB1 13 0 1,13 0 2基因与慢性型乙型肝炎的关系及其在临床诊断和判断预后中的作用。方法 :采用序列特异性引物聚合酶链反应 (PCR -SSP)对 2 3例慢性重型乙型肝炎和 3 0例慢性乙型肝炎患者进行HLA -DRB1 13 0 1,13 0 2的检测。结果 :HLA -DRB1 13 0 1,13 0 2在慢性重症乙型肝炎组显著高于慢性乙型肝炎组 ( 82 6%vs 3 0 %,χ2 =10 0 4,P <0 0 5 ,RR =11 0 83 )。结论 :HLA -DRB1 13 0 1,13 0 2基因与慢性重型乙型肝炎的发生有关。
Objective: To investigate the relationship between HLA-DRB1 13 0 1, 13 0 2 gene and chronic hepatitis B and its role in clinical diagnosis and prognosis. Methods: HLA-DRB1 13 0 1,13 0 2 was detected in 23 cases of chronic severe hepatitis B and 30 cases of chronic hepatitis B by sequence-specific primer polymerase chain reaction (PCR-SSP). Results: HLA-DRB1 13 0 1,13 0 2 was significantly higher in patients with chronic severe hepatitis B than in patients with chronic hepatitis B (82 6% vs 30%, χ 2 = 10 0 4, P 0 05, RR = 11 0 83). Conclusion: The HLA-DRB1 13 0 1,13 0 2 gene is associated with the development of chronic severe hepatitis B