我们从1996年起对临床患者下肢创伤弧菌感染引起创伤弧菌脓毒血症的流行病学及临床特点、临床早期诊断依据(标准)、临床早期抗菌药物及清创减压引流、截肢等综合治疗以及创伤弧菌脓毒血症小鼠模型、致病性及抗菌药物实验治疗等方面进行了临床与实验的系列研究。1.流行病学及临床特点:患者男:女比为2.1:1,平均年龄50.3岁,发病在4～10月,多居住在温州沿海村镇,职业为渔民或农民,大多有长期嗜酒的不良习惯,有长期嗜酒 We started from 1996 epidemiology and clinical features of Vibrio vulnificus V. Sepsis infection in clinical patients, early clinical diagnosis based on (standard), clinical early antimicrobial agents and debridement, amputation, etc. Comprehensive treatment and Vibrio vulnificus septic mice model, pathogenicity and experimental treatment of antibiotics and other aspects of clinical and experimental series of studies. 1. Epidemiology and clinical features: Male: female ratio of 2.1: 1, the average age of 50.3 years old, incidence in 4 to 10 months, and more live in coastal villages and towns in Wenzhou, occupation as a fisherman or farmer, most of them have long-term alcohol Bad habits, long-term alcohol