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胶质细胞源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF)是转化生长因子(transforming growth factorβ,TGF-β)家族中的一员。GDNF是一种神经营养因子,通过与由GDNF家族受体(GDNF family receptor alpha1,GFRα1)和c-Ret组合成的复合受体结合,激活细胞内一系列信号传导通路,发挥营养神经、抑制神经元变性坏死的作用。多项实验室及临床研究显示,GDNF对多巴胺(dopamine,DA)能神经元和外周的神经元如交感神经元、副交感神经元、感觉神经元与运动神经元等有营养和保护作用。最有希望成为治疗帕金森病(parkinson’s disease,PD)、肌萎缩侧索硬化症(amyotrophic lateral sclerosis,ALS)及外周神经元变性坏死的有效治疗手段。如何通过采用恰当的给药途径及方式,既能使其在体内高效稳定地发挥作用,又能将不良反应减到最低程度是未来研究的努力方向。
Glial cell line-derived neurotrophic factor (GDNF) is a member of the transforming growth factor (TGF-β) family. GDNF is a neurotrophic factor that activates a series of signaling pathways within the cell by binding to a complex receptor composed of the GDNF family receptor alpha1 (GFRα1) and c-Ret. It functions as a vegetative nerve and suppresses nerves The role of yuan degeneration and necrosis. A number of laboratory and clinical studies have shown that GDNF can nourish and protect dopamine (DA) -like neurons and peripheral neurons such as sympathetic neurons, parasympathetic neurons, sensory neurons and motor neurons. It is most promising to be an effective treatment for the treatment of Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and peripheral neuron degeneration and necrosis. How to use the appropriate route of administration and ways to make it both efficient and stable in the body, but also minimize the adverse reactions is the direction of future research efforts.