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目的：探讨川芎嗪对慢性低Ｏ２高ＣＯ２大鼠肺动脉压力及肺动脉管壁胶原的影响。方法：将ＳＤ大鼠３０只分为：对照组（Ａ），低Ｏ２高ＣＯ２组（Ｂ），低Ｏ２高ＣＯ２＋川等嗪组（Ｃ），低Ｏ２高ＣＯ２时间为４周。结果：（１）Ｂ组肺动脉平均压（ｍＰＡＰ）显著高于Ａ组（Ｐ＜０．０１），Ｃ组ｍＰＡＰ显著低于Ｂ组（Ｐ＜０．０１），３组间平均颈动脉压无显著差异（Ｐ＞０．０５）；（２）电镜显示Ｂ组肺动脉胶原纤维较Ａ组明显为多，Ｃ组较Ｂ组明显为少。免疫组化显示Ｂ组肺动脉Ⅰ型胶原含量（平均吸光度值ＬＤ）较Ａ组明显为高（Ｐ＜０．０１），Ｃ组较Ｂ组明显为低（Ｐ＜０．０１），Ⅲ型胶原ＬＤ各组间无明显差异（Ｐ＞０．０５）；（３）Ｂ组血浆内皮素浓度高于Ａ组，血清ＮＯ－２／ＮＯ－３低于Ａ组，Ｃ组血浆内皮素浓度低于Ｂ组，ＮＯ２－／ＮＯ３－高于Ｂ组，Ｐ均＜０．０１。结论：川芎嗪可预防慢性低Ｏ２高ＣＯ２性肺动脉高压的形成和肺动脉管壁胶原的沉积。
Objective: To investigate the effects of ligustrazine on pulmonary arterial pressure and pulmonary artery wall collagen in chronic hypoxic hypercapnia rats. Methods: Thirty SD rats were divided into control group (A), hypoxic hypercapnia group (B), hypoxic hypercapnic CO2 + transthyretin group (C), hypoxic hypercapnia time was 4 weeks. Results: (1) The mean pulmonary arterial pressure (mPAP) in group B was significantly higher than that in group A (P <0.01), while the mPAP in group C was significantly lower than that in group B (P <0.01) (P> 0.05). (2) Electron microscopy showed pulmonary artery collagen fibers in group B were significantly more than those in group A, while those in group C were significantly less than those in group B. Immunohistochemistry showed that the content of type I collagen (average absorbance value LD) of pulmonary artery in group B was significantly higher than that in group A (P <0.01), but lower in group C than that in group B (P <0.01) (3) The concentration of endothelin in group B was higher than that in group A, while the level of NO-2 / NO-3 in group B was lower than that in group A B group, NO2- / NO3- than B group, P <0.01. Conclusion: Tetramethylpyrazine can prevent the formation of chronic hypoxic hypercapnic pulmonary hypertension and pulmonary artery wall collagen deposition.