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目的:探讨神经节苷脂治疗新生儿缺氧缺血性脑病(HIE)的疗效。方法:将73例新生儿缺氧缺血性脑病患儿随机分为治疗组37例和对照组36例,均给予综合治疗,治疗组在此基础上,加用神经节苷脂治疗。观察两组临床症状、体征恢复情况及治疗前、治疗1个疗程后和生后28d各进行NBNA评分。结果:治疗组和对照组总有效率分别为94.59%和72.22%(χ2=6.65,P<0.01);两组患儿治疗1个疗程后NBNA评分分别为36.38±1.32和34.43±2.15,P<0.05;生后28d的NBNA评分分别为38.47±2.13和35.36±1.92,P<0.05。结论:神经节苷脂治疗HIE有明显疗效。
Objective: To investigate the efficacy of ganglioside in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE). Methods: A total of 73 neonates with hypoxic-ischemic encephalopathy were randomly divided into treatment group (37 cases) and control group (36 cases). All patients were given comprehensive treatment. On the basis of this, the treatment group was treated with ganglioside. The clinical symptoms and signs of the two groups were observed and NBNA scores were assessed before treatment, after one course of treatment and after 28 days of birth. Results: The total effective rates of the treatment group and the control group were 94.59% and 72.22% (χ2 = 6.65, P <0.01). The NBNA scores of the two groups were 36.38 ± 1.32 and 34.43 ± 2.15 respectively after one course of treatment, P < 0.05; NBNA score of 28 days after birth were 38.47 ± 2.13 and 35.36 ± 1.92, respectively, P <0.05. Conclusion: Ganglioside treatment of HIE has a significant effect.