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慢性肾功能衰竭的常见并发症之一就是尿毒症性脑病,该病症状包括疲劳、情感淡漠、情绪不稳定、睡眠障碍和脑电描记术结果表现异常。一项新的动物研究表明,肾机能不全情况下的大脑机能障碍在一定程度上可归因于大脑中蛋白的硝化作用,这种蛋白的硝化作用可通过氧自由基介导。美国加利福尼亚大学的资深研究人员Nosratola Vaziri解释说,肾功能衰竭动物的大脑有可能出现较高的反应性氧化物活性,且神经元氧化氮合成水平提高。研究人员假设患尿毒症性脑病动物大脑中的酪氨酸硝化作用可能也有所增高。
One of the common complications of chronic renal failure is uremic encephalopathy, symptoms of which include fatigue, apathy, mood swings, sleep disorders and abnormal electromyographic findings. A new animal study shows that brain dysfunction in the case of renal insufficiency is due in part to the nitration of proteins in the brain that is mediated by oxygen free radicals. Nosratola Vaziri, a senior researcher at the University of California, Los Angeles, explained that it is possible for the brain of a kidney failure animal to exhibit higher reactive oxygen species activity and increase neuronal nitric oxide synthesis. Researchers hypothesize that tyrosine nitration may also be increased in animal brains with uremic encephalopathy.