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目的:对我院收集到的药物不良反应(ADR)进行分析,为合理用药提供参考。方法:回顾性分析2006～2008年我院收集到的217例ADR报告表,按患者性别、年龄、原患疾病、药物名称、给药途径、不良反应表现等进行统计分析。结果:抗感染药引起的ADR居首位(其中以喹诺酮类居多),其次为中药制剂。喹诺酮类和中药注射剂的ADR临床表现以循环系统反应和皮肤损害为主。本次报告中发现9例严重ADR。其中加替沙星引发3例,克林霉素引发2例。结论:喹诺酮类药和中药注射剂是ADR监测重点,临床上应严格掌握适应证,合理使用,减少ADR的发生。
Objective: To analyze the adverse drug reaction (ADR) collected in our hospital and provide a reference for rational drug use. Methods: A retrospective analysis of 217 ADR reports collected in our hospital from 2006 to 2008 was performed. Statistical analysis was performed according to patient’s gender, age, original illness, drug name, route of administration and adverse reaction. Results: ADR caused by anti-infectives ranked first (among them quinolones was the most), followed by traditional Chinese medicine preparations. The clinical manifestations of quinolones and traditional Chinese medicine injections are mainly circulatory system reactions and skin lesions. The report found 9 cases of severe ADR. Among them, gatifloxacin caused three cases and clindamycin caused two cases. Conclusion: Quinolones and traditional Chinese medicine injections are the key points of ADR monitoring. Clinical indications should be strictly followed and used rationally to reduce the occurrence of ADR.