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目的:探讨2型糖尿病肾病患者血清中IL-6、TNF-α、一氧化氮(NO)和内皮素(ET)水平及其临床意义。方法:采用相关试剂盒,按其说明书检测93例2型糖尿病患者血清IL-6、TNF-α、NO与ET水平。结果:单纯糖尿病组(SDM组)、隐性糖尿病肾病组(IDN组)、显性糖尿病肾病组(ODN组)IL-6、TNF-α与ET水平较对照组明显升高,其中ODN组最高(P<0.01)。SDM组、IDN组、ODN组NO较对照组明显减少(P<0.01),其中ODN组最少。IL-6与UAER、TNF-α、ET均成正相关,NO与IL-6、TNF-α呈负相关。结论:IL-6、TNF-α、NO与ET可能参与2型糖尿病肾病的发病及病理变化过程,检测患者IL-6、TNF-α、NO与ET水平可作为判断预后、指导治疗的指标。
Objective: To investigate the serum levels of IL-6, TNF-α, nitric oxide (NO) and endothelin (ET) in patients with type 2 diabetic nephropathy and their clinical significance. Methods: The levels of IL-6, TNF-α, NO and ET in 93 patients with type 2 diabetes mellitus were detected by using the kit. Results: The levels of IL-6, TNF-α and ET in SDDM group, IDN group and ODN group were significantly higher than those in control group, with the highest in ODN group (P <0.01). Compared with the control group, NO in SDM group, IDN group and ODN group was significantly decreased (P <0.01), and ODN group was the least. IL-6 was positively correlated with UAER, TNF-α and ET, and NO was negatively correlated with IL-6 and TNF-α. CONCLUSION: IL-6, TNF-α, NO and ET may be involved in the pathogenesis and pathological changes of type 2 diabetic nephropathy. Detecting the levels of IL-6, TNF-α, NO and ET may be used as an index for prognosis and guide therapy.