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最近在伦敦召开的关于甲氰咪胺的国际性专题讨论会上,不仅讨论了它在消化性溃疡和食管炎中的应用,也探讨了该药在胰腺炎和胃肠道出血方面的治疗价值。 由于胰腺机能不全(包括由胰腺炎或胰腺切除引起者〕所致的吸收不良患者,补充胰酶并不能使脂肪泻减轻,其原因是酶在胃内被胃酸不可逆性地灭活,或在十二指肠的酸性pH中降低了它的活性,尤其当胰腺疾病引起胃酸分泌过高时。另一个有害的作用是低pH能促进胆酸沉淀并与饮食中的蛋白质相结合。
At an international symposium on cimetidine recently held in London, not only its use in peptic ulcer and esophagitis was discussed, but also its therapeutic value in pancreatitis and gastrointestinal bleeding was explored . Supplementation with trypsin does not reduce steatorrhea due to poor malabsorption in patients with pancreatic insufficiency (including those caused by pancreatitis or pancreatic excision) due to irreversible inactivation of the enzyme in the stomach by gastric acid, or in ten Its activity in the acidic pH of the duodenum is reduced, especially when pancreatic disease causes hypersecretion of the stomach acid. Another harmful effect is that low pH promotes cholic acid precipitation and binds to proteins in the diet.