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硝苯吡啶(Nifedipine,Nif)能抑制跨膜Ca~(++)内流,使运动诱发的哮喘减轻,但对组胺引起的哮喘的保护作用尚有争议。为此,作用对比了硝苯吡啶对运动性哮喘及组胺诱发哮喘的缓解作用,且阐明其作用的可能部位。8例证实有运动性哮喘的男性病人,试验时病情稳定,1秒钟用力呼气量(FEV_1)>预计值的70%;12小时内禁用色甘酸钠、皮质类固醇或支气管扩张剂;研究前6周无上呼吸道感染史。全部病例随机分
Nifedipine (Nif) inhibits the transmembrane Ca ~ (++) influx and reduces motor-induced asthma, but the protective effect of histamine-induced asthma is controversial. To this end, the role of nifedipine on exercise-induced asthma and histamine-induced asthma relief, and clarify the possible role of the site. Eight male patients with exercise-induced asthma were stable at the time of the trial with FEV 1> 70% of their predicted value; sodium cromoglycate, corticosteroids, or bronchodilators were banned within 12 hours; prior to the study 6 weeks history of upper respiratory tract infection. All cases randomized