论文部分内容阅读
近十年来,利用聚合物装置和渗透系统已成功地设计了几种控释给药系统,使药物从胃肠道释放或透皮吸收,获得比一般剂型波动较小的血药浓度。此类给药系统在治疗上有下列优点:其体内释药速率可根据体外实验数据来预测,降低血药峰浓度从而减少药物的副作用;预告和延长药物的作用时间;减少病人的服药次数;为临床药理提供研究工具,并可代替静脉滴注等。然而仅有少数给药系统真正具有大的治疗意义,因为给药系统重点在于提供相对平稳的血药水平,
In the past decade, several controlled release drug delivery systems have been successfully designed using polymer devices and osmotic systems to release or transdermally absorb drugs from the gastrointestinal tract to obtain less concentrated plasma concentrations than typical dosage forms. Such delivery systems have the following advantages in therapy: their rate of drug release in vivo can be predicted from in vitro experimental data, reducing peak plasma concentrations and thereby reducing the side effects of the drug; predicting and prolonging the duration of the drug; decreasing the number of patient dosing; Provide research tools for clinical pharmacology, and can replace intravenous drip. However, only a few drug delivery systems have real therapeutic implications since the dosing system is focused on providing relatively stable blood drug levels,