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目的研究大戟科有毒中药千金子的化学成分。方法采用开放硅胶柱色谱、Sephadex LH-20、ODS等方法分离化合物,运用现代波谱技术确定化合物的结构。结果从千金子乙醇提取物的氯仿萃取部分分离纯化得到9个化合物,分别鉴定为1-hydroxyl-3,5,8-trimethoxyxanthone(1)、1,5-dihydroxyl-3,8-dimethoxyxanthone(2)、秦皮啶(fraxidine,3)、6,7-二羟基香豆素(esculetin,4)、6-甲氧基-7羟基香豆素(scopoletin,5)、邻羟基苯甲酸(salicylic acid,6)、乌苏酸(ursolic,7)、金色酰胺醇酯(aurantiamide acetate,8)、(E)-8-oxooctadec-9-ennoic acid(9)。结论化合物1-3,9为首次从大戟属植物中得到,化合物6-7为首次从续随子植物中得到。
Objective To study the chemical constituents of Euphorbiaceae poisonous Chinese medicine Qianjin. Methods The compounds were isolated by silica gel column chromatography, Sephadex LH-20 and ODS. The structures of the compounds were determined by the modern spectroscopy. Results Nine compounds were isolated and purified from the chloroform fraction of the ethanolic extract, and identified as 1-hydroxyl-3,5,8-trimethoxyxanthone (1), 1,5-dihydroxyl-3,8- , Fraxidine (3), 6,7-dihydroxycoumarin (4), 6-methoxy-7-hydroxycoumarin (5), salicylic acid ), Ursolic (7), aurantiamide acetate (8), (E) -8-oxooctadec-9-ennoic acid (9). Conclusions Compounds 1-3 and 9 were obtained from Euphorbiaceae for the first time, and compounds 6-7 were obtained from the continuous cotyledons for the first time.