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187例停经49d以内的早孕妇女分别单独使用抗孕激素(Mifepristone,RU486)600mg一次口服(28例)和RU486 600mg一次口服,365后加16,16-双甲基-反式-⊿~2前列腺素E_1甲酯(ONO802)lmg阴道栓剂(159例)诱导流产,结果:完全流产率分别为39.3％和93.7％,不完全流产率为25.0％和5.0％,继续妊娠率为35.7％和1.3％。从用RU486到子宫开始流血的天数分别为3(1～6)d和1(2/3(1(1/2～2)d。用药开始至妊娠物排出的天数为4.4(3～6)d和1(2/3)(1(1/2～8(1/2))d。两组副反应较轻。RU486对于阻断早孕有效,单独使用不全流产的发生率高,与少量ONO 802合用是诱导早孕妇女流产高度有效和副反应少的一种方法。
A total of 187 primiparous women within 49 days of menopause were treated with 600 mg oral once (28 cases) of Mifepristone (RU486) alone and RU486 600 mg orally once daily for 365 days followed by 16,16-bis-methyl-trans- The results showed that the rate of complete abortion was 39.3% and 93.7% respectively, the rate of incomplete abortion was 25.0% and 5.0%, the rate of continuing pregnancy was 35.7% and 1.3% respectively . The number of days bleeding started from RU486 to the uterus was 3 (1-6) d and 1 (2/3 (1 (1-2/2) days, respectively. d and 1 (2/3) (1 (1/2 ~ 8 (1/2)) d. The side effects were mild in both groups.RU486 was effective in blocking early pregnancy and had a low incidence of incomplete abortion 802 is a combination of induction of early pregnancy women abortion is highly effective and less side effects of a method.