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Objective: To evaluate five indigenous Mexican plants [Hippocratea excelsa, Hippocratea celastroides, Argemone mexicana(A. mexicana), Tagetes lucida, and Pseudosmodingium perniciosum(P. perniciosum)] toxicity against the fourth instar larvae of the dengue primary vector, Aedes aegypti(A. aegypti).Methods: Each plant part was treated successively with hexane, ethyl acetate, acetone, and methanol to extract potential active components of the plants against the dengue vector.Results: There was a range of toxicity at 24 or 48 h post-exposure for the different plant parts and organic solvent used(LC50 values ranged between 20 and 890 μg/mL). Extracts from seeds of A. mexicana(hexane washing with methanol and acetone) and stem-bark of P. perniciosum(hexane) showed highest toxicity to Ae. aegypti larvae at 48 h post-exposure(LC50 values were80, 50, and 20 μg/mL, respectively), thus making them potential candidates as biolarvicides.Efforts are on-going to characterize the bioactive components of the extracts, through chromatography, for their use as biological tools for the control of the primary dengue vector.Conclusions: A. mexicana and P. perniciosum are good candidates to combat the dengue vector, Ae. aegypti, as they were highly toxic to the larvae.
Objective: To evaluate five indigenous Mexican plants [Hippocratea excelsa, Hippocratea celastroides, Argemone mexicana (A. Mexicana), Tagetes lucida, and Pseudosmodingium perniciosum (P. Perniciosum)] toxicity against the fourth instar larvae of the dengue primary vector, Aedes aegypti A. aegypti). Methods: Each plant part was treated with hexane, ethyl acetate, acetone, and methanol to extract potential active components of the plants against the dengue vector. Results: There was a range of toxicity at 24 or 48 h post Extracts from seeds of A. mexicana (hexane washing with methanol and acetone) and stem-bark of P. perniciosum (hexane) -exposure for the different plant parts and organic solvent used (LC50 values range between 20 and 890 μg / mL) showed the highest toxicity to Ae. aegypti larvae at 48 h post-exposure (LC50 values were 80, 50, and 20 μg / mL, respectively), thus making them potential candidates as biolarvicides. Efforts are on-going to characterize the bioactive component s of the extracts, through chromatography, for their use as biological tools for the control of the primary dengue vector. Conclusions: A. mexicana and P. perniciosum are good candidates to combat the dengue vector, Ae. aegypti, as they were highly toxic to the larvae.