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药物依赖是遗传因素、心理因素和社会环境等多因素所致的疾病[1]。脑内伏隔核、纹状体、杏仁核和嗅区等区域是毒品依赖的神经解剖基础,脑内黑质纹状体通路、中脑边缘叶通路和中脑皮质通路等信号通路与毒品依赖病理生理过程密切相关[2]。多巴胺系统参与毒品依赖病理生理过程[1-3]。近年来发现大麻素系统与毒品依赖病理生理过程有关。大麻素系统主要由神经递质、受体及其降解酶组成,神经递质主要是花生四烯酸乙醇胺(Ananadamide,
Drug dependence is a genetic disease, psychological factors and social environment and other factors caused by the disease [1]. Cerebral nucleus accumbens, striatum, amygdala and olfactory area and other areas is the basis of drug-dependent neuroanatomy, brain nigrostriatal pathway, midbrain edge of the leaf and the cerebral cortex pathways and other signaling pathways and drug dependence Pathophysiology is closely related to [2]. Dopamine systems are involved in drug-dependent pathophysiological processes [1-3]. In recent years, cannabinoid system and drug-dependent pathophysiological processes were found. Cannabinoid system is mainly composed of neurotransmitter, receptor and its degradation enzyme, neurotransmitter is mainly arachidonic acid ethanolamine (Ananadamide,