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目的:探讨氨甲喋呤(MTX)不同给药方式在异位妊娠保守治疗中的效果及适应症的选择。方法:回顾性分析我院2005年1月～2006年6月住院确诊的异位妊娠病例中,选取符合保守治疗条件的110例随机分成两组,分别采用单次组和分次组肌肉注射MTX的治疗方法,观察两组成功率、住院时间、药物副作用等指标。结果:单次组和分次组肌肉注射治疗异位妊娠的成功率无显著性差异(P>0.05),单次组药物副作用明显低于分次组。保守治疗成功率与血β-HCG值有关(P<0.05)。结论:两种方法治疗异位妊娠的成功率相同,成功率与血β-HCG值有关。单次注射治疗副反应发生率低,是一种较好的保守治疗方法。
Objective: To investigate the effect of methotrexate (MTX) in different modes of administration on the conservative treatment of ectopic pregnancy and the choice of indications. Methods: A retrospective analysis of our hospital from January 2005 to June 2006 hospitalized cases of ectopic pregnancy, selected conservative treatment of 110 cases were randomly divided into two groups, respectively, single and sub-group intramuscular injection of MTX Treatment, observation of success rate of two groups, hospital stay, side effects of drugs and other indicators. Results: There was no significant difference in the success rate of intramuscular injection of single-dose or sub-group of ectopic pregnancy (P> 0.05). The side-effects of single-dose group were significantly lower than those of sub-group. Conservative treatment success rate and blood β-HCG value (P <0.05). Conclusion: The success rates of the two methods in treating ectopic pregnancy are the same, and the success rate is related to the blood β-HCG value. A single injection of low incidence of side effects, is a better conservative treatment.