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目的:联合检测直肠癌患者血清CA199、CA242水平,探讨其预后价值。方法:采用放射免疫法检测46例直肠癌患者术前及术后第7天、1和3个月的血清CA199、CA242水平变化,并与31名健康体检者对照。结果:直肠癌患者血清CA199、CA242水平较对照组明显升高(P<0.001,P<0.001),且术后复发转移组与未复发转移组比较血清CA199、CA242水平差异有统计学意义(P<0.001,P<0.001),结肠癌患者术后第7天CA199、CA242水平较术前均明显下降(P<0.001,P<0.001);而在复发转移组中,术后1个月血清CA199、CA242较术后第7天差异有统计学意义(P<0.05,P<0.05);术后3个月升高更明显(P<0.01,P<0.01)。结论:动态监测血清CA199、CA242水平变化情况,对于直肠癌的诊断及术后复发转移的早期判断有一定临床指导价值。
Objective: To detect the serum levels of CA199 and CA242 in patients with rectal cancer and to explore the prognostic value. Methods: The serum levels of CA199 and CA242 in 46 patients with rectal cancer before and 7 days, 1 and 3 months after operation were detected by radioimmunoassay and compared with 31 healthy controls. Results: The serum levels of CA199 and CA242 in patients with rectal cancer were significantly higher than those in the control group (P <0.001, P <0.001), and the levels of serum CA199 and CA242 in patients with recurrent and metastatic disease were significantly different (P <0.001, P <0.001). The levels of CA199 and CA242 on the 7th day after operation in colon cancer patients were significantly lower than those before operation (P <0.001, P <0.001), while in the recurrence and metastasis group, the serum CA199 (P <0.05, P <0.05). The level of CA242 increased significantly at the third month after operation (P <0.01, P <0.01). Conclusion: Dynamic monitoring of serum CA199, CA242 level changes have some clinical value for the diagnosis of rectal cancer and early diagnosis of postoperative recurrence and metastasis.