葡萄胎的病因迄今未明。有关本病的病因学研究,过去根据对本病的传统认识(地理分布差别大),多着眼于环境因素,一直未获突破性进展。七十年代后期,开始有较多遗传方面的研究问世。现整理所读文献,结合个人研究体会,综述如下: 一、有关环境因素的假说主要有:①营养不良说:最早提出并被广泛引用;主要根据流行病学调查资料,认为本病高发于东南亚等发展中国家,可能与营养不良有关。然而此说不但一直缺少有力的证据,而且有越来 The cause of hydatidiform mole is unknown so far. The etiology of the disease research, the past based on the traditional understanding of the disease (geographical distribution of large differences), more focus on environmental factors, has not been a breakthrough. The late seventies, began to have more genetic aspects of research come out. Now finishing the reading of the literature, combined with personal experience, summarized as follows: First, the hypothesis about environmental factors are: ① malnutrition said: the first proposed and widely cited; mainly based on epidemiological survey data, that the disease high in Southeast Asia And other developing countries, may be related to malnutrition. However, this has not only been a lack of strong evidence, but also more and more