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目的:探讨解磷注射液抢救急性有机磷中毒(AOPP)的临床效果。方法:采用历史对照法,治疗组为1997年以后103例,用解磷注射液即刻肌注或静注并持续使用3天,辅以氯磷定使用3～7天;对照组1993～1996年86例,采用传统方法,即使用足量阿托品静滴使迅速达“阿托品化”并维持治疗量至治疗结束,辅以氯磷定即肌注或静滴并持续3～5天。结果:治愈率治疗组97.1％,对照组82.6％(P<0.01);阿托品用量,治疗组94.34±28.39mg,对照组449.19±146.83mg(P<0.001);乐果中毒反跳,治疗组32例反跳2例死0例,对照组30例反跳9例死6例(P<0.05);住院天数,治疗组6.88±2.10天,对照组10.03±3.26天(P<0.001)。结论:采用解磷注射液抢救AOPP疗效显著优于传统阿托品化法。
Objective: To investigate the clinical effect of Phosphorus-Phosphate Injection in the rescue of acute organophosphate poisoning (AOPP). Methods: The historical control method, the treatment group was 103 cases after 1997, with phosphoric acid injection immediate intramuscular or intravenous injection and continued use of 3 days, supplemented with chlorophosphorus use of 3 to 7 days; control group from 1993 to 1996 In the 86 patients, the traditional method was to use intravenous infusion of enough atropine to rapidly achieve “atropine” and to maintain the therapeutic dose until the end of treatment. Intravenous or intravenous infusion of chlorophosphorus was continued for 3 to 5 days. Results: The cure rate was 97.1% in the treatment group and 82.6% in the control group (P <0.01). The dosage of atropine was 94.34 ± 28.39 mg in the treatment group and 449.19 ± 146.83 mg in the control group (P <0.001) There were 2 cases died of bounce in 0 cases, 30 cases in control group, 9 cases died in 6 cases (P <0.05). The days of hospitalization were 6.88 ± 2.10 days in treatment group and 10.03 ± 3.26 days in control group (P <0.001). Conclusion: The treatment of AOPP with Phosphate Injection has a significantly better efficacy than the traditional atropisol treatment.