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报道了大鼠对尼美舒利与吗啡、苯巴比妥的依赖性研究。结果表明，用尼美舒利处理的大鼠，突然停药或给予纳络酮未观察到戒断症状；吗啡组大鼠突然停药或用纳络酮诱导，可观察到明显的戒断症状；苯巴比妥处理大鼠突然停药后，也可观察到戒断症状；对于吗啡和苯巴比妥依赖的大鼠，尼美舒利没有替代作用。
Reported the dependence of nimesulide and morphine and phenobarbital in rats. The results showed that no withdrawal symptoms were observed in rats treated with nimesulide abruptly or with naloxone; withdrawal symptoms were significantly abolished in morphine rats or induced by naloxone Phenobarbital-treated rats were also abstinence-relieved after withdrawal; nimesulide had no alternative effect on morphine and phenobarbital-dependent rats.