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目的 :观察格拉诺赛特治疗急性淋巴细胞白血病化疗后致白细胞减少症的疗效。方法 :设立治疗组 3 0例 ,化疗后出现白细胞或中性粒细胞减少则应用格拉诺赛特治疗 ,对照组 2 0例 ,仅化疗及一般对症支持治疗。观察两组患儿外周血WBC变化及WBC持续低于 2× 10 9/L的天数 ,及两组感染发生情况。治疗组白细胞上升至 4× 10 9/L后复查骨髓了解细胞形态。结果 :用格拉诺赛特治疗后 3天WBC较治疗前明显升高 ,WBC持续低于 2× 10 9/L的天数明显缩短 ,感染发生率下降 ,差别有统计学意义 (P <0 0 5 )。结论 :格拉诺赛特治疗急性淋巴细胞白血病化疗后致白细胞减少症是有效的 ,且能降低感染率 ,保证化疗顺利进行。副作用少 ,不会导致白血病细胞增殖
OBJECTIVE: To observe the effect of granuocet on leucopenia after chemotherapy for acute lymphoblastic leukemia. Methods: The treatment group was established 30 cases, after chemotherapy, leukocyte or neutropenia should be treated with granuloside, control group 20 cases, only chemotherapy and general symptomatic supportive treatment. The change of WBC in peripheral blood and the number of days in which WBC continued to be lower than 2 × 10 9 / L were observed and the incidence of infection in both groups was observed. Treated group leukocytes increased to 4 × 10 9 / L after review of bone marrow to understand cell morphology. Results: WBC was significantly increased 3 days after treatment with granonet, and the number of days with WBC less than 2 × 10 9 / L was significantly shortened and the incidence of infection was decreased with a statistically significant difference (P <0.05 ). Conclusion: Granolacete is effective in treating leukopenia after chemotherapy in patients with acute lymphoblastic leukemia, and can reduce the infection rate and ensure the smooth progress of chemotherapy. Less side effects, does not lead to leukemia cell proliferation